Buying, holding and selling guitars can pay off. I've seen one guy on YouTube that claims to make a living at it but he doesn't buy new.
If a guitar is purchased new at a 'normal' street price it's going to take one heck of a long time for the guitar to rise again to the price paid. Collector guitars don't become collectable over night unless there is a notable provenance surrounding the instrument. Moreover, the story behind PRS might also work against someone hoping a PRS guitar will hold its value. Unlike other major manufacturers, PRS seems to have a rep of producing better guitars every year. That is, there's not much history of PRS guitars made in the good old days when quality workmanship and quality materials were evident. It's my perception that the market views current PRS instruments better than past ones because the company's namesake constantly drives to do it better. In other words, PRS turned out quality instruments in the past and will turn out higher quality instruments in the future if the perceived trend continues.
So, in my view, playing a new guitar far outweighs the potential payoff at the end of a multi-year (decade?) span in a closet.
"It takes a lot of devotion and work, or maybe I should say play, because if you love it, that's what it amounts to. I haven't found any shortcuts, and I've been looking for a long time."
-- Chet Atkins