First if your playing a piggy back (head n cab) get a monster pro studio 1000 speaker cable to plug in from the head to cab, you'll be amazed at how much this will reduce sound, if your hooking straight up into a combo then try a good ol monster cable (can't go wrong) a nice 20 ft studio 1000 from sam ash is only like 140 bucks heh. well don't need to go that overkill....umm bring your gear into your nearest guitar store and try out some of their higher end cables to see if that does the trick, if not try out a noise gate, and if that still doesn't do the trick for some reason get better pickups =/