Even if I had the same gear as you, I would only be able to give you some guidelines. The rest is a matter of your personal taste, and what your ears tell you.

For the kind of tone you seek, you will not need much distortion. Some compression will help to keep the dynamics under control.

EQ decisons are purely a matter of taste. You may find that the neck pickups works best for you, at least to start, but you may also find that having both pickups on allows you to add some colouration to the tone. Avoid heavy bass, because that can muddy the tone. Use just enough treble to bring out the detail.

Keep experimenting. Keep playing. Most of the blues tone comes from the player's hands. The equipment and settings are less important, really.