I got my 4x12 Blue Voodoo cab last week (sounds really good with the right head settings), and I just ordered a BOSS GE-7 graphic eq which I'm going to run through the effects loop. So now my primary rig is:
Kramer Striker 422> Blue Voodoo fx loop out > Moreley Sapphire Flanger > Arion Digital Delay > Boss GE-7 > Voodoo fx loop return (and of course, the 120 watt head feeds into the 4x12 cab.

The last time I was in the studio, I ran an old Rockman Distortion generator straight into the board's seven band eq. With the eq dialed up right, the rig sounds like Master of Puppets with some extra sustain and harmonics.