I've never seen Family Guy, but I couldn't imagine it being better than the Simpsons. Especially the early Conan Obrien days with stuff like the Monorail.
Major drag for me is I've seen every episode so many times I have trouble finding it funny now.... I know all the lines before they come up.
Wish somebody would invent something you could plug into your brain and selectively delete memories some of your favorite movies and tv shows so you could watch em again.