Bill's back. Flip a multi-pole single coil pickup and hear the difference? I don't think so!
However, Zepo should be a politician (reading the end of his reply).
Flip a r/h guitar (i.e. strings transposed) and you've immediately lost intonation as well as string slide through the nut. The typical bridge rake doesn't allow for saddle adjustment to compensate, so the guitar can't be tuned properly. Come on, admit it, a lefthander has real obstacles if he can't afford a bespoke instrument!
PonyOne, you must be unique!
"Its what you DON'T play that sets you apart from the mundane."