It's all personal preference in what sounds good to your ear.
Single coils are brighter, twangier, have less output, and are noisy (a lot of hum when not playing).
Humbuckers are fatter, offer more sustain, more output, and quiter (that's how they got the name humbucker, they buck the hum). They discovered that by putting 2 single coils next to each other, they cancel out that annoying hum that comes from single coils.
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