The only guitars that I've heard with similar sounds are Smashing Pumkins (sometimes) and Dean Wareham (from Galaxie 500 and Luna).
Will this work?... humbucker -> compressor (using a very strong ratio) -> a tube-type OD pedal (saturated with tube compression) -> another OD/booster (like a Fulltone Fulldrive) -> Wah pedal (pushed down to squash out some of the high frequencies) -> a tube amp (with the preamp tubes pushed way-too-hard)
Please - send me any suggestions you may have, as I am an acoustic guitarist by nature and this electric stuff is uncharted territory for me.
Thanks