Yes. Tube amps will sound different at different volumes... generally alot better when cranked.
I agree that using the mids is a good idea with this amp because it is what its good for.
I dont know about having to change the settings a lot when crank the amp though.
By virtue of their electrical properties, tubes generate a special waveform when they're saturated, which is why tube engineering has tremendous tonal advantages over solid state or DSP solutions, particularly for crunch and lead sounds. Tubes enter the saturation zone gradually or softly, which lends tube-driven tone its trademark yet totally unique character.