Really the only thing I change on the amp is reverb. OK, I change my pickups alot, but i leave the tone and volume at one spot. I have my Blues Driver set for a hollow overdrive and my tubescreamer for a fuzzy/hot lead tone. EQ with cut highs, delay for an almost "welcome to the jungle" sound, but a little less.
I saw this guy at a battle of the bands, and I think he fiddled with his pedals after every song. I didn't notice much of a difference.
Electric Guitars are the inspiration for cries of "Turn that damn thing down"-Gibson website