Im currently running on a Marshall valvestate, setting my distortion channel wide open and bass treble middle @ max
no effects, just the standard marshall distortion.
My BC Rich guitar gives an incredible raw agressive heavy metal sound :) ---> 2 BC Rich BDSM Humbuckers
When I play metallica I dont hear any difference(Espessialy the old albums like And Justice, Master etc).
So I would say Practice like a M*th*r F*ck*r because Jamyz Hetfield aint a pussy playing guitar. He is a truely underrated guitarist.
If your technique is good, and your using fairly good equipment you should be able to get that sound.