What I found helps is just to create your own preset, take all the effects off, and start by choosing an amp simulation that you like the sound of... then build it up from there. For a good lead sound, you'll likely want to combine an amp sim and a pedal simulation, just like you would with a real amp. It can be a little tricky at first to figure out which "amp" and which "pedal" (overdrive or distortion) you like the combined sound of, and how much each should be driven to get a good combined result. What worked for me was to just use my ears, and do it just like you would with a real amp and overdrive or distortion pedal... get a decent sounding drive sound from the amp that you like, then add a distortion or overdrive and use that to push your sound to where you want it. Then add delay, noise-reduction, whatever else you want.
Have fun!