Yeah, single coils are a different beast from humbuckers. I'm a sucker for smooth fat tone, so on my strat, I tend to use my neck pickup. The middle pickup seems to have a signature strat sound which I like too - reminds me of some of the tones that SRV and Eric Johnson would get. I only use the bridge pickup if I'm covering a tune and want to replicate the sound.
Humbuckers are nice too with the extra umph on the output. You can really drive your amp HARD!!