I don't have two notes to pick from a major key, it's a little easier to pick the prominent soloing notes in a minor key.
But I can say that using the notes from the chord being played underneath is very effective in major key soloing.
I think the sus 4 sounds good in major soloing. If there were a D major chord being played, It sounds nice to bend from an F# to a G (first string, 2nd fret), then release and land on the D (3rd fret, 2nd string).
Soloing around the chord shapes like this really makes the notes pop out.
"Thanks for clarifying -I recall another GT instructor saying that rock can be summed up as playing minor scales over major keys"
This can be a little misleading. But, if you take an E minor scale at the 12 fret and move the whole pattern down to the 9th fret you'll have an E major scale pattern. This is an easy way to learn two scales for the price of one.
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