If you are talking about the exact same sequence of notes, I guess it would be purely an expression thing. Timing, maybe some bend or vibrato, yet keeping the whole sequence primarily the same.

...And that to me is really the ticket to playing lead: conveying the expression you want. There are only 7 basic notes in a scale after all. How do we have so much different sounding music over all this time with only that to build on? Kind of remarkable when you think about it.