All that said (and all good points), try setting your amp clean & neutral, and set your Digi to Fender-something.

I've got the RP250, so I don't know what's on your 500 for options (can't remember all my own lol). If you have any Tweed or Bassman, give them a try.

On any guitar, I just find the neck pick up or neck/middle has a nice "default" Bluesy sound for my taste.

Start clean, see if you like it. EQ to taste. For some SRV, dial in a lil Tubescreamer. ;)