Yeah, Duriel is the big worm thing at the end of the second act.
Well, maybe "one hit" was a bit of an exaggeration. But I got trashed pretty quick. And since you lose experience when you die in Nightmare difficulty I wasn't eager to try again.
The problem is that he freezes you as soon as you come in the room. You can't do hit and run attacks, or any of that.
I still have my characters all backed up. I've got a pretty good amazon too, so maybe I'll give it another go. Do you ever play on Battlenet?