It depends an awful lot on what you want to spend.
Speaking economically then, in my very humble opinion, if you have no preference over humbuckers or single coils, then a Squier Strat (made by Fender) would be a good bang for the buck. (For that matter you can get HSS configured Squiers.) I have an SSS and while it's not as solid-feeling as spending a grand on a Fender Stratocaster, I really (really) like it and would not part with it unless/until it's replaced with an actual Fender Strat.
You might look at Epiphone for more of a Gibson style. I have a Special II, which is an entry level Epiphone LP style. I got it to save wear & tear on my Gibson, but now it's actually my go-to guitar. Feels real nice and solid to me and I like the tone.
If you are looking around, have a check at
http://www.harmony-central.com/ for gear reviews on anything you find interesting. Take your time, making the purchase. And take reviews with a grain of salt, too. In the end it really matters what feels & sounds best to
you.
...so ever since then, I always hang on to the buckle.