Short answer: No.

Long answer, maybe a couple of drinks is enough to loosen you up a little and let go, anything more makes you clumsy and sloppy. You're also more likely to decide that something pretty stupid (like lighting the carpet on fire or detuning two octaves, turning your amp all the way up, and playing with WAY too much uncontrolled delay) is actually a rather cool idea.

I hate trying to play when I'm too drunk.