I posted this a few days ago as an instrumental but deleted it & decided to go back and jam a lead to it instead.
Done on a Mac Core 8 using Cubase 4.3 and a Roland Guitar Synth.

Drums done with Battery 3 and a Yamaha Drum Pad
Bass is an ARP2600 playing an arpeggio.
Keyboards/Strings/other stuff is either Halion or a loop of some kind.
Harmonies were done on 16 tracks then copied 4 times and panned.
Guitar is a Gibson 1975 L6S Deluxe through a Boss GT-8 and patched directly into the computer.
Acoustic is a Yamaha Eterna.
Classical guitar was something I bought off eBay and it was missing a string but hey..only $40
Guitar Synth is a 1984 Roland GR700
Mic is a Rode NT-1
Mixer is a Behringer MX802A
The ending harmony/string thing is kinda tagged on cause it's the beginning of the next song.

http://s93744050.onlinehome.us/GameIsOver_Schmange.mp3

... just in case the previous version without the lead was better...

http://s93744050.onlinehome.us/GameIsOverInst_Schmange.mp3