It's got a 1/8" headphone output so, yeah. You might need a 1/8" to 1/4" converter for your headphone plug.
Only thing I find is that regardless of the processor, the overdrive always seems to sound a little cheezy.
Like, I've got a Boss GT-8 that I use straight line in, but to tone down the overdrive I use a Redbox Cabinetulator through the send/receive jacks.
It's sorta like a cabinet simulator that takes that fuzzy edge off the overdrive built into the effects unit.
I did a video going through the some of the patches on the GT-8 here:
http://guitartricks.com/lesson.php?input=10991Even when I use that though, for recording I still sometimes run it through a clean channel using Amplitube.