I use a Fender Mexi hss strat, digitek rp200 pedal into a peavey bandit 112. I have used this same set-up for the past 6 months.
Changing pick-ups did not make a difference, and the volume and tone of the guitar were all on 10 the whole time. Moving the cable did not make a difference.
Of course, I cannot recreate the problem when I am trying figure out what component is the offender.
Any ideas? I plan to start with the cable-just cause I am cheap.