I know a guy that has a Fender strat with a humbucker at the bridge and a Sustainer at the neck.... and he runs two seperate circuits in his guitar... with two jack outputs.... into to seperate amps. He plays a lot of slide in open tunings.... And he gets a really crazy layered sound by running two amps becuase he can run one clean channel and one dirty channel all at once with one guitar... Normally he runs the sustainer output into a clean amp with some chorus effect to get a nice wide tone that's laid underneath his lead tone which is either his humbucker, single in the middle, or both... It's a pretty crazy tone-monster type of setup... It's just really hard to run all that stuff through a standard vintage (not tub) routing of a strat.... So it was a pretty custom project with a lot of routing/body work and wiring... But basicially it's two seperate guitar electronics systems... both are very basic... but both operate independently... The tone controls on the guitar itself only control the bridge and middle pickups... The sustainer is hard wired through an on/off switch... and the volume/tone controls are strictly through the amp... He has pedals hooked up to control the chorus/overdrive/phaser/tremolo... etc... It's a crazy setup but he does a lot of weird stuff like that. Sounds verrrry cool too. It's like having two guitars playing but there's only one. He's his own rhythm and lead parts....