first thing's first:
Play with people you get along with really well, and be sure you're playing music that satisfies you.

Next thing:
make sure you're having a good time

final thing:
don't be suprised at bad nights, bum audiences, or all those people who say "sure thing, I'll be there" when you're flyering or talking to your friends that never show up for the gig.

If you can cope with all of that, you'll be ok.