If you want like the ultimate shredder tone without any pedals and stuff,

get these:

Amp:
gain- 3-5 o' clock
treble- 1 o' clock
middle- 12 o' clock
bass- 2 o'clock

Guitar:
pickup- neck or middle
volume- 10/10
tone- 5/10

just remember to keep the EQ around 12 o' clock and never have full tone.