im a bit of a fan of dropping the 6th string down a step to make booming powerchords really easy to do, so DADGBE / CGCFAD - afterall you can still play any song with DADGBE that relies on standard tuning as long as your not using the 6th string :P and when u want to crunch up the distortion and scare the cat you can pull a bar powerchord and switch really quickly :P

There's a certain satisfaction from playing Rammstein - Du Hast on DADGBE, it's hard to describe :P