The Ibanez Tubescreamer, depending on which model, is definetly more of a add-on to a nice tube amp. I would never use the tubescreamer alone ( I have one ). I always use it to boost up my overdriven tube amp and the results are great. Others you may want to look into are the BOSS Blues Driver and Super Overdrive.
Electric Guitars are the inspiration for cries of "Turn that damn thing down"-Gibson website