Not sure if this would be my ultimate dream guitar, but here's what I've been fantasizing about building sometime in the future.
BODY STYLE: standard Tele
BODY WOOD: Swamp Ash
PUP ARRANGEMENT: bridge humbucker, middle and neck single coils
CONTROL LAYOUT: Chrome Tele control plate w/ 1vol, 1tone, 5-way switch & toggle switch to split the bridge humbucker
COLOR: Tobacco Burst on front and back
NECK PROFILE: mix between a PRS wide fat and a 59 LP
NECK WOOD: Flamed Maple
FB WOOD: Brazillian Rosewood
INLAY'S: Custom Mother of Pearl
HEADSTOCK: Custom shape w/ Swamp Ash Laminate to match body
NECK FINISH: Clear Satin
NUT: GRAPHTECH
TUNNERS: Schaller Locking tuners
BRIDGE: Chrome Gotah Tele bridge cut for Humbucker
PICKGUARD: not sure yet (probably pearloid)
One done by Ron Thorn would probably be a close second. Similar to this one, but with a TOM or wraparound bridge: