Hey all,
As Douglas said alot of it is his touch, or what I would call technique. I can get really close with a tele, Fender Hot Rod Deville 212, compressor, and some distortion.

Set your clean sound first, and you may want to add a little more sustain. You want a little scream when you hold the note for a couple of seconds. After you get the depth of the tone figured out, add your distortion.

I also like it when he plays clean too, he's just a great player no matter what effects he uses.