yep - you can/should always use more than one piece of spyware removal.. I was just thinking in the "free" realm...

another one I have that is awesome is webroot spysweeper. it found another 140 traces of software that spybot missed... they're both good software but they don't all get the same updates...

another way to get rid of popups and spyware - use google... search for the specific one that is giving you a hard time and there is usually info out there on how to remove it.

for the pc savvy try this site..

www.blackviper.com this dude has a few good tutorials on how to shut down different services on Win2k and XP Pro to stop hackers....