I've had little experience with such a drastic down tuning on my guitar as it really kinda sounds like crap on mine. Might be different for others though. I came to the conclusion that if I wanted to hit those notes I'd have to wait until I got a 7 string guitar since it's a guitar that's made for that kind of note and I wouldn't have to worry about tuning back up. Course now I use my pedal effect to lower the pitch down however many steps I want. Only flaw with that is it means I can't use the wah pedal in the same song. Such is the sacrifice though, I guess.