I'm the same as Trent. I'm left handed but whenever I played around with friends guitars they were always regular strung guitars so it just seemed "normal" to me even as a lefty. Now that I am really trying to learn guitar I find I have a bit of a hard time using a pick well but it doesn't slow me down at all if I just use my fingers. I'm sure that I would be lost if I tried to switch to a lefty guitar now. Most lefties are ambidextrous so we have a bit of an advantage because of that.

I played violin as a kid and I found I had an advantage then because my left hand was quite a bit stronger then most of the other kids so working the neck came quite natural.