I've found that I get a thicker sound with a little less distortion than I used to think was necessary. With my Boss MT-2, I like to have the lows pumped, the highs at around 1 o'clock, the outer mid dial at 2 o'clock and the smaller mid dial at 10 o'clock. The distortion I set to taste, normally between 9 and 1 o'clock. I used to crank it, but found that there was better note clarity and "chunk" between 9 and 1 o'clock.
I almost never switch off the neck pickup (I just prefer the tone and volume), and I like to keep the tone dial at 10 and I play around with the volume a bit, but normally it's at 10 also.
Try that out, see what happens let us know. Keep asking 'till you get a good answer. Oh, and try the search function.
e.g. Click here - aren't you proud of me, Lordathestrings?.... heh heh, this thread showed up in the search...
... and that's all I have to say about that.
[U]ALL[/U] generalizations are [U]WRONG[/U]
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[U]ALL[/U] generalizations are [U]WRONG[/U]
[/sarcasm]