In the video he's using a Strat. He used a lot of Fenders, I think he preferred Jaguars, if I'm not mistaken. A Strat with the bridge pickup selected and some chorus would probably do a good job of replicating the clean section of Smells Like Teen Spirit. For the distorted part, just remember that less is more.
... and that's all I have to say about that.
[U]ALL[/U] generalizations are [U]WRONG[/U]
[/sarcasm]