I like the settings suggested in the manual. Generally I keep it on the "Heavy Metal" setting and tweak from there. I've found that less "Distortion" generally is better (i.e. 10 - 11 o'clock). I love cranking the bottom end, though. And playing with the middle frequency boost/cut is lots of fun, too and brings out different interesting tones.

Hope you end up loving it as much as I do!