Hi there,
Yes, we've had a number of left-handed guitar players learn from our courses. There is going to be a little difference since you have to think of it as a mirror when watching the lessons. But I think with some practice, you'll be able to pick up on it just fine.
Guitartricks' founder is even a lefty himself, so I think you'll be fine too!
If you have any questions, comments, or concerns, please contact us.