Hi Deanhorneck,
There's nothing you have to do with the nut, it should be fine for the most part. But if you want to be super sure, you can tell us what type of guitar you have?
If you switch to a new string gauge, it's always best to have it set up again by a professional or someone you know that can do it, or you can learn how to do it yourself, as well!
If you have any questions, comments, or concerns, please contact us.