Not really, I don't think.

Stacked rigs will tend to have, for instance, 4x12 cabs, rather than the 1x12 or 2x12s you normally get with combos.

Because the separate head/cab systems tend to be bought by the better off musicians, they often have more features - maybe more channels, switchable EQ or FX loops and so on, but that varies manufacturer to manufacturer and amp to amp.