The only open tuning I've ever tired was open D5 when I was learning a Creed song.
See, when you tune your guitar to an open chord, its so you can play chordes using only the slide, not your fingers, you can stop all the srings at only one fret and get a chord, unlike standard tuning.
If your only playing a solo or melody line, you dont really need open tuning, the slide just makes it sound neater, like in You Aint Seen Nothin Yet by BTO, or This Flight Tonight by Nazareth, those are cool slide guitar lines.