I love the pickups in the American Strats, well any strat for that matter. I hate the sound of those ibanez guitars, and their pickups, i don't know why, its just personal preference i guess.
DiMarzio has made some good pickups, as well as Seymour Duncan.
I think if you tweak your settings enough on at least a decent pickup/humbucker, you'll get some good tone, alot of it is just preference.