If you change gauge you will probably need to reset your intonation. This is not hard if you have a good tuner as all you need to do is adjust the scale length at the bridge until your open note and the note fretted at the 12th fret are the same (only an octave higher). If there is a following wind you will not have to mess with your truss rod and all will be well.

Im using Ernie Ball 10s and 9s on my strats and PRS 9s on the CE24 at the moment. The PRS strings are a little more expensive and Im still tiring to decide if there worth it !