You should definitely rest your wrist as this can lead to long term damage. So maybe take some time off or cut your practice time down. Also, this could be an issue based on your posture or the way you're holding the guitar. You want to make sure your fretting hand is more or less parallel with the floor. You never want to overbend your wrist.

Things that are important:

Proper exercises- Gently stretch your wrist, fingers, arms back and shoulders.

when practicing make sure you're taking breaks.