I've read a lot of good things about the SE line. The price point of an SE is certainly more attractive :-).

I liked the PRS, but I find I'm partial to the tones of a Strat or a LP. I'm sure this is because all of my guitar heroes growing up played either of these instruments.

I would definitely consider a PRS as a "3rd" guitar...or a gigging guitar. At SE prices, I might be able to justify that. At the price point of the S2, I couldn't justify it.