Originally Posted by: CSchlegelYou can do either.
Slightly more complex blues players will target chord tones. This means you mostly just use one scale, but use the notes of that scale to emphasize the notes of each chord as they happen.

Still more blues players approach it more like a jazz player, they totally follow the chord changes & alter the scale as necessary.

Thats kind of what I was looking for.

Thanks for the help and the links!
You are the man!