A nice place to start is to use your neck pick up.
Then on your amp put your sound the cleanest you can, then add distortion to your desire. Using the normal or birght channel is usually a good place to start. The "blues sound" is usually pretty clean. Some guitarist will add a lot of distortion (Stevie Ray Vaughan for exemple) but the sound will still be fairly clean. You can hear all the notes very well.
Personally ,after those steps, I will put the bass around 6 on the amp and trebble to 10. After that I would play with the knobs on my guitar until I have the sound I want.

Playing with knobs and switches to get the sound you like is a life long task :p Your ears and your style will keep progressing and you will always find new inspiration. So you will never be 100% satisfied with your sound. The best you can do is try to hit that 99% :)


Oooh also. I dont know your amp but tube amps helps to get that warm sometimes dirty sound that blues player have.