I would add that there are neck radius differences too. There is the 50's era style which is rounder/thinker and on various 50's reissues and the current Studio. The 60's era profile such as on the Traditional which is slimmer and more tapered then the 50's. Then the Asymetrical such as on the current Standard.
While the beefier neck radius like the 50's profile will add to the tone and sustain a bit, it may be a consideration depending on the size of your hand. My ES has a 50's radius neck and is still pretty comfortable to play and my hands are not particularly large. Still, neck radius is a consideration.