First of all, you have no mention of the melody. Without that factored in I can only make suggestions on chord function.

Originally Posted by: FlyingJbird
I need to figure out a way to get back to Emaj7. I can't just go there, because D#7b5 resolves to an Emin7, not maj. Any ideas?

Actually, D#7b5 resolves to D. It's a tritone substitution for an A7.

If you want to get back to E, then cycle five your way there from C.

C - F - Bb - Eb - Ab - Db - Gb - Cb (which is B and therefore the V of E) > E

Or you can do the stereotypical 4 chord cycle five jazz turnaround:

G#min7 - C#7b9 - F#min7 - B7b9 > E

Or you could simply change your chord voicing to function correctly:

Cmaj - Cmaj7 - D7 - D#dim7

Now your D# chord is a vii dim of E and will move to E quite nicely.