My amp is a Line 6 Spider II combo amp. It has a headphone/ direct out jack.
I've tinkered with some VST amp sims and think they're pretty neat in playback mode, but when I try to play "live" I have a latency issue. (I'm running Vista 64 bit and by all accounts across the net there's no real solution for this delay). It's more than a little distracting striking a chord and hearing it a split second later come out of my speakers...
What about a POD or similar device?