My setup is pretty simple when you follow each signal path. I have three different paths. The only effects I use anymore is distortion/overdrive, chorus, delay, and reverb.

I just have routed them to several amps because I play about anything from country to heavy metal. There is no way to get great country or jazz music out of a Laney or Marshall. You gotta have a Fender Twin for country. I have never been able to get great heavy metal out of a Fender Twin. It is just too clean. One type of distortion box can't do everything. One type of amp or guitar can't do everything. If they did every band and guitar player would sound exactly the same on every song and CD.