Sorry, first day of vacation and I'm already getting stupid. I think if you listen to different rock songs or blues songs, different artists will have different sounds. I think you would have to have some different settings depending on what you wanted to hear. In general, though I like the overdriven plexi sound for more classic rock, distortion pedals for more on the metal side. Blues is more of an overdrive sound than distortion. (To me anyway, there will be lots of exceptions.) Choose your amp model, but I always like that Fender Twin sound for blues. Just my sound pref, really, not that it matches any particular style or song.
...so ever since then, I always hang on to the buckle.